I am fed up! 受够了。I am fed up with 脑白金’s commercial. It is on TV all the time. 我真是有点厌恶脑白金的广告了,电视节目里老是它的广告。“受够了某人”也可以说:I have had enough of Shi, he made a fortune by selling snake oil. 这个史真是让我烦,他靠卖狗皮膏药发了大财, or I have had enough of his bad behavior.